研究方向


袁晶教授课题组,欢迎保研和考研同学,请联系
yuanjing@xmu.edu.cn


研究方向

  研究领域(Research Area)

    疟疾是寄生性原生动物---疟原虫感染导致的传染性疾病,每年导致数亿人口感染和约50万人死亡。由于缺乏高效疟疾疫苗,加之疟原虫耐药,疟疾的全球防控依然面临巨大挑战。疟原虫生活周期(生活史)复杂,在两个截然不同的宿主-按蚊和脊椎动物之间交替寄生。课题组专注疟原虫双宿主寄生的适应性机制,揭示疟原虫宿主寄生和宿主转换的遗传和分子机制,为阻断疟原虫感染、寄生和传播提供新策略,为疟疾药物和疫苗设计提供新标靶。



    课题组研究方向包括:

  1. 疟原虫按蚊传播中感染和寄生的分子细胞机制。疟原虫是单细胞真核生物,在雌性按蚊和脊椎动物动物两个宿主间交替传播,经历不同细胞阶段和显著差别的细胞形态和细胞功能。疟原虫如何在不同宿主阶段完成感染,寄生和传播?我们以鼠疟原虫-小鼠-按蚊为模型,重点关注疟原虫有性生殖的如下过程。

配子体形成;

配子体激活成为配子(配子发生);

雌雄配子受精成为合子;

合子(受精卵)变形为动合子;

动合子获能穿越按蚊消化道上皮;

动合子转化成卵囊。


  2. 开发和优化基因组修饰工具CRISPR/Cas9,提高疟原虫基因功能解析的效率。


近三年以通讯作者在《Science Advances》、《EMBO Journal》、《Nature Communications》、《Current Biology》、《EMBO Reports》、《mBio》等杂志发表多篇论文,上述文章第一作者均为课题组研究生。欢迎加入我们的团队。

最新文章



袁晶教授课题组,欢迎保研和考研同学,请联系
yuanjing@xmu.edu.cn


16.Pengge Qian#, Xu Wang#, Cuirong Guan#,  Xin Fang, Mengya Cai, Chuan-qi Zhong, Yong Cui, Yanbin Li, Luming Yao, Huiting Cui*, Kai Jiang* and Jing Yuan*
Apical anchorage and stabilization of subpellicular microtubules by apical polar ring ensures Plasmodium ookinete infection in mosquito.
Nature Communications, (2022)13:7465.(此处全文链接)


15.Pengge Qian#, Xu Wang#, Chuan-Qi Zhong#, Jiaxu Wang#, Mengya Cai, Wang Nguitragool, Jian Li*,Huiting Cui* and Jing Yuan*
Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite.
eLife, (2022)::e77447.(此处全文链接)


14.Meng Liu#, Gangqiang Guo#, Pengge Qian#, Jianbing Mu#, Binbin Lu, Xiaoqin He, Yanting Fan, Xiaomin Shang, Guang Yang, Shijun Shen, Wenju Liu, Liping Wang, Liang Gu, Quankai Mu, Xinyu Yu, Yuemeng Zhao, Richard Culleton, Jun Cao, Lubin Jiang, Thomas E Wellems*, Jing Yuan*, Cizhong Jiang* and Qingfeng Zhang*.
5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes.
Proceedings of the National Academy of Sciences of the United States of America, (2022):e2110713119.(此处全文链接)


13.Zhenke Yang#, Yang Shi#, Huiting Cui#, Shuzhen Yang, Han Gao and Jing Yuan*.
A malaria parasite phospholipid flippase safeguards midgut traversal of ookinetes for mosquito transmission.
Science Advances, (2021):eabf6015.(此处全文链接)


12.Zhenkui Li#, Huiting Cui#, Jiepeng Guan, Cong Liu, Zhengang Yang and Jing Yuan*.
Plasmodium transcription repressor AP2‐O3 regulates sex‐specific identity of gene expression in female gametocytes.
EMBO Reports, (2021):e51660.(此处全文链接)


11.Chuanyuan Liu#, Zhenke Yang#, Mengya Cai, Yang Shi, Huiting Cui and Jing Yuan*.
Generation of Plasmodium yoelii malaria parasite for conditional degradation of proteins.
Molecular & Biochemical Parasitology, 2021, 241:111346.(此处全文链接)


10.Xu Wang#, Pengge Qian#, Huiting Cui#, Luming Yao and Jing Yuan*.
A protein palmitoylation cascade regulates microtubule cytoskeleton integrity in Plasmodium.
The EMBO Journal, (2020):e104168.(此处全文链接)


9.Yuanyuan Jiang#, Jun Wei#, Huiting Cui#, Chuanyuan Liu, Yuan Zhi, ZhengZheng Jiang, Zhenkui Li, Shaoneng Li, Zhenke Yang, Xu Wang, Pengge Qian, Cui Zhang, Chuanqi Zhong, Xinzhuan Su and Jing Yuan*.
An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites.
Nature Communications, 2020, 11(1):1764.(此处全文链接)


8.Han Gao#, Zhenke Yang#, Xu Wang#, Pengge Qian, Renjie Hong, Xin Chen, Xinzhuan Su, Huiting Cui and Jing Yuan*.
ISP1-anchored polarization of GCβ/CDC50A complex initiates malaria ookinete gliding motility.
Current Biology, 2018, 28(17):2763-2776.(此处全文链接)


7.Cong Liu#, Zhenkui Li#, Yuanyuan Jiang, Huiting Cui* and Jing Yuan*.
Generation of Plasmodium yoelii malaria parasite carrying double fluorescence reporters in gametocytes.
Molecular & Biochemical Parasitology, 2018, 224:37–43. (此处全文链接)


6.Pengge Qian#, Xu Wang#, Zhenke Yang, Zhenkui Li, Han Gao, XinZhuan Su, Huiting Cui* and Jing Yuan*.
A Cas9 transgenic Plasmodium yoelii parasite for efficient gene editing.
Molecular & Biochemical Parasitology., 2018; 222:21-28.(此处全文链接)


5.Cui Zhang#, Zhenkui Li#, Huiting Cui#, Yuanyuan Jiang, Zhenke Yang, Xu Wang, Han Gao, Cong Liu, Shujia Zhang, XinZhuan Su* and Jing Yuan*.
Systematic CRISPR-Cas9-Mediated Modifications of Plasmodium yoelii ApiAP2 Genes Reveal Functional Insights into Parasite Development.
mBio, 2017, 12:8(6).(此处全文链接)


4.Cui Zhang#, Han Gao#, Zhenke Yang, Yuanyuan Jiang, Zhenkui Li, Xu Wang, Bo Xiao, XinZhuan Su, Huiting Cui* and Jing Yuan*.
CRISPR/Cas9 mediated sequential editing of genes critical for ookinete motility in Plasmodium yoelii.
Molecular & Biochemical Parasitology, 2017, 212:1-8.(此处全文链接)


3.Cui Zhang#, Bo Xiao#, Yuanyuan Jiang#, Yihua Zhao#, Zhenkui Li, Han Gao, Yuan Ling, Jun Wei, Shaoneng Li, Mingke Lu, XinZhuan Su, Huiting Cui* and Jing Yuan*.
Efficient Editing of Malaria Parasite Genome Using the CRISPR/Cas9 System.
mBio, 2014, 5(4):01414-14. (此处全文链接)


2.Jing Yuan#, Ken Chih -Chien Cheng#, Ronald Johnson, Ruili Huang, Sittiporn Pattaradilokrat, Anna Liu, Rajarshi Guha, David Fidock, James Inglese, Thomas E Wellems, Christopher Austin* and Xinzhuan Su*.
Chemical genomic profiling for antimalarial therapies, response signatures and molecular targets.
Science, 2011, 333:724-729.(此处全文链接)
Research article and Cover; Recommended “Exceptional” by “Faculty of 1000 Biology”


1.Jing Yuan#, Ronald L Johnson, Ruili Huang, Jennifer Wichterman, Hongying Jiang, Karen Hayton, David A Fidock, Thomas E Wellems, James Inglese, Christopher P Austin and Xinzhuan Su*.
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nature Chemical Biology, 2009, 5(10):765-71.(此处全文链接)