[Image: Ethan Tyler and Alan Hoofring, Division of Medical Arts, National Institutes of Health]  

   A pair of chemical compounds (light blue and purple) target wild-type and mutant forms of the Plasmodium falciparum chloroquine resistance transporter, which mediates the parasite's (yellow) resistance to the widely used antimalarial drug. Using high-throughput chemical and genetic analyses, Yuan et al. identify potential new antimalarial drugs that could be used in combination to suppress the development of drug resistance.

Chemical genomic profiling for antimalarial therapies, response signatures and molecular targets.pdf